Specifically, the team will identify these susceptibility genetic markers using the technique of a whole genome association study to compare the frequency of more than one million genetic variants between individuals whose colon cancers never metastasized, versus those whose colon cancers were metastatic at the time of diagnosis, and versus individuals whose colon cancers relapsed and metastasized following initial complete surgical resections. By identifying genetic markers that track with individuals who have developed cancer metastases, the team will seek to hone in on and identify the underlying metastasis susceptibility genes; identify the causative metastasis susceptibility variants present in these genes among different ethnic groups; determine if these variants or genes also impart susceptibility to metastasis in other common solid tumors; and determine the biologic pathways by which these susceptibility alleles promote cancer metastasis.

Acceptance of this paradigm will result in the identification of entirely new biological pathways that will be key to the management and prognosis of colon cancer, and to developing new and more effective anti-cancer therapies.

Source: Case Western Reserve University